Exploring DNA damage mechanism at molecular, subcellular, cellular, and multicellular levels
Primary Supervisor: Assoc. Prof. Lynn Paterson – Heriot-Watt University
With the increased use of lasers in medicine comes the challenges to assess genotoxicity and mutagenicity to identify hazardous effects of novel laser sources. Different in vitro and in vivo methodologies assess various endpoints such as change of chromosome number or structure, point mutations or DNA single or double-strand breaks. In this project, we will employ novel bioengineering and biophysics tools and techniques (microfluidics, microfabrication, novel optical fibres, imaging). By exploiting these microengineering and optical technologies we hope to develop new high throughput screening devices that allow continuous, multiple measurements to better understand the DNA damage mechanism due to laser exposure at molecular, subcellular, cellular, and multicellular levels. Please apply if you have a background in any of the following areas or related fields: physics, bioengineering, cell biology, biomaterials, biomedical engineering, molecular biology, biotechnology.
Informal enquiries can be sent via email to L.Paterson@hw.ac.uk
For a more detailed description please see our vacancies as advertised on FindAPhD.